TICH has successfully served as a secretariat for a range of health initiatives, including the Lake Region Economic Block (LREB), and functioned as the Secretariat for the Social Aspects of HIV/AIDS Research Alliance (SAHARA) for Eastern and Central Africa from 2004 to 2010. Additionally, TICH has been an active member of the African Malaria Network Trust (AMANET, 2012) and participated in the Teasdale-Corti Grants IDRC-funded project in 2014. This project involved collaboration with universities from Ottawa, Alberta, the West Indies, North West, and South Africa, focusing on leadership hubs to strengthen District Health Systems performance in sub-Saharan Africa and the Caribbean.

As a Centre of Research Excellence for Health Systems Strengthening (CRESS), TICH has facilitated knowledge exchange and strategic planning across multiple countries. The organization has established key partnerships with prominent entities such as WHO, UNICEF, and the Rockefeller Foundation in Kenya, Tanzania, Ethiopia, and Malawi, which led to the development of the TICH DHS performance improvement model. Furthermore, the training of managers and service providers in Kenya in 2014, funded by DFID and the Global Health Research Initiative (Canada), resulted in TICH being contracted to develop the Ministry of Health's Community Health Strategy which is the government’s current framework.

These initiatives have enabled TICH to significantly enhance health service delivery and research capacity across Africa. Through its diverse programs, TICH has produced substantial outputs, including training materials, technical reports, and peer-reviewed publications, all contributing to health system strengthening and policy development continent-wide. TICH’s collaborative approach, emphasizing partnership building and resource sharing, has solidified its position as a leader in health systems capacity building and research excellence in Africa.